Alexander S. Ham

This study identifies c-MAF as a mediator of motoneuron activity in maintaining fast-glycolytic muscle fibers and neuromuscular junctions through chromatin accessibility changes and gene regulation.

The paper uses single-nuclei RNA-sequencing to identify NMJ-specific transcripts and shows that Etv4 and Pdzrn4 contribute to NMJ stability through gene regulation and protein interactions.

This study shows that mTORC1 inhibition in adult mice does not cause muscle atrophy or functional decline, despite metabolic and morphological changes.