Ruiyang He

The paper identifies and characterizes a novel intestinal epithelial cell type that co-expresses epithelial and lymphoid genes, distinct from known cell types.

This study identifies a tumor-cell MHC-II program linked to immunotherapy outcomes in bladder cancer across different stages and treatment settings.

The paper develops a computational framework to jointly analyze transcriptional and mechanical signals in spatial transcriptomics data from mouse embryos, identifying predictive signatures of tissue compartment boundaries.

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

This study investigates transcription factor dynamics during human enteroendocrine cell differentiation, finding that oscillations of ASCL1 and NEUROD1 enable accurate cell type diversification.

The paper identifies the adult mouse intestinal stem cell niche as a multi-layered structure with distinct mesenchymal and smooth muscle cell populations that regulate ISC proliferation and differentiation.