Judith Kraiczy

Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

Delineation and birth of a multi-layer intestinal stem cell niche

The paper identifies the adult mouse intestinal stem cell niche as a multi-layered structure with distinct mesenchymal and smooth muscle cell populations that regulate ISC proliferation and differentiation.

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

This study creates a single-cell atlas of human liver development, identifying pathways and factors that guide hepatic cell fates and improving hepatocyte-like cell functionality.

Culture Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

This study shows that long-term culture of human intestinal organoids leads to DNA methylation changes, altered gene expression, and functional shifts, suggesting potential confounding effects in research.