Discovery of non-canonical proteins through modification-aware proteogenomics
Valeriia Vasylieva, Enrico Massignani, Tine Claeys, Francis Bourassa, Sébastien Leblanc, Ihor Arefiev, Lennart Martens, Marie A. Brunet
This paper demonstrates that using ionbot with OpenProt improves detection of non-canonical proteins by reducing FDR and increasing reproducibility compared to TPP.
bioRxiv · Aug 20, 2026 · PreprintMolecular Biology