Andrey Damianov

This study identifies RBM5's role in regulating splicing by activating DHX15 and blocking spliceosome progression, with implications for cancer-related splicing dysregulation.

This study shows that the SF3B1 K700E mutation causes widespread changes in U2/branchpoint recognition without altering 3' splice site selection.

The paper identifies a non-coding risk variant in GBA1 associated with Parkinson's disease in African ancestry populations, showing it disrupts splicing and reduces glucocerebrosidase activity.

The paper identifies RBM5 and RBM10 as U2 snRNP subunits that interact with intron branch sites and regulate splicing by acting as silencers.

The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.