An Xist-dependent protein assembly mediates Xist localization and gene silencing
Amy Pandya‐Jones, Yolanda Markaki, Jacques Serizay, Tsotne Chitiashvili, Walter Mancia, Andrey Damianov, Constantinos Chronis, Bernadett Papp, Chun‐Kan Chen, Robin McKee, Xiaojun Wang, Anthony C. Chau, Shan Sabri, Heinrich Leonhardt, Sika Zheng, , Kathrin Plath
The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.
Nature · Sep 9, 2020Peer-reviewedMolecular Biology