Activation of amino acid metabolic program in response to impaired glycolysis in cardiac HIF1 deficient mice
Ivan Menendez-Montes, Beatriz Escobar, Manuel J. Gómez, Teresa Albendea-Gomez, Beatriz Palacios, Elena Bonzón‐Kulichenko, Ana Vanessa Alonso, Alessia Ferrarini, Luis Jesús Jiménez‐Borreguero, Jesús Vázquez, Silvia Martı́n-Puig
The paper investigates the effects of HIF1 deletion in cardiac progenitors, finding that it leads to impaired glycolysis and activation of an amino acid metabolic program without affecting heart development or function.
bioRxiv · May 23, 2020 · PreprintDevelopmental Biology