Manuel J. Gómez

Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle

This study shows that gut Enterococcus faecalis induces trained immunity in myeloid bone marrow progenitors via the C-type lectin receptor Mincle, contributing to inflammation linked to gut permeability.

An ATF4-centric regulatory network is required for the assembly and function of the OXPHOS system

This study identifies ATF4 as a critical regulator of OXPHOS assembly and function by analyzing human and murine cell lines with OXPHOS defects.

Neuregulin-1 regulates cardiomyocyte dynamics, cell cycle progression, and maturation during ventricular chamber morphogenesis

This study identifies Nrg1-ErbB2/4-pErk signaling as critical for cardiomyocyte cell cycle progression, migration, and trabeculation during ventricular development, with implications for cardiac regeneration.

Activation of amino acid metabolic program in response to impaired glycolysis in cardiac HIF1 deficient mice

The paper investigates the effects of HIF1 deletion in cardiac progenitors, finding that it leads to impaired glycolysis and activation of an amino acid metabolic program without affecting heart development or function.

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

This study identifies a Dll4-Jag1-EphrinB2 signaling cascade that regulates coronary arterial development in mice.

Nanog regulates Pou3f1 expression and represses anterior fate at the exit from pluripotency.

This study identifies Nanog as a repressor of Pou3f1, which inhibits anterior neural fate during gastrulation in mouse embryos.

Metabolic reprogramming from glycolysis to amino acid utilization in cardiac HIF1α deficient mice.

This study investigates the effects of HIF1α deletion in cardiac progenitors during heart development, finding that HIF1 is dispensable for cardiac growth and reveals metabolic reprogramming toward amino acid utilization.