Author

Arya Lalezarzadeh

University of California San DiegoORCID 0009-0002-1986-7598Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Aida Mestre‐FarreraiD· 1 shared Dong‐Er ZhangiD· 1 shared Hannah E. Majeski· 1 shared Helen M. Piwnica-WormsiD· 1 shared Jane YangiD· 1 shared Kei‐ichiro ArimotoiD· 1 shared Laurent FattetiD· 1 shared Shirong CaiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aida Mestre‐FarreraORCID

Mutual co-authors in cluster

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1 paper

Recent·Most cited

Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction

Zhimin Hu, Hannah E. Majeski, Aida Mestre‐Farrera, Shirong Cai, Arya Lalezarzadeh, Yichi Zhang, Kei‐ichiro Arimoto, Dong‐Er Zhang, Helen M. Piwnica-Worms, Laurent Fattet, Jane Yang

This study shows that TYK2 suppresses breast cancer metastasis under low ECM stiffness by promoting EMT, and its localization changes with ECM rigidity.

Nature Communications · Mar 25, 2026Peer-reviewedCancer Biology