Tianxiang Li

This paper identifies HNK as a compound that targets astrocytic μ-δ opioid receptor heterodimers to mediate antidepressant effects through Gs signaling and CREB activation.

This study shows that the rostral prelimbic cortex's excitation/inhibition balance modulates passive coping behavior, which is affected by chronic stress and reversed by the fast-acting antidepressant HNK.

This study investigates how retrieved memories direct behavior by showing how transient and sustained neurons in the dmPFC interact with the locus coeruleus to modulate freezing responses to conditioned threats.