Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices
Matthew W. Becker, Matthew E. Brown, Katherine Wiseman, Ana Laura Chiodetti, Mollie K. Huber, Alexandra E. Cuaycal, Pumin Sintara, Sandra Mara Ferreira, Dylan Smurlick, Jessie M. Barra, Andrew M. Ladd, Denise Minerva Drotar, Mark A. Atkinson, Peter Weber, Hussein Al‐Mossawi, , Edward A. Phelps
This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.
bioRxiv · Oct 21, 2025 · PreprintBioengineering