Author

Denise Minerva Drotar

University of Florida HealthORCID 0000-0002-8538-6875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Mark A. AtkinsoniD· 2 shared Todd M. BruskoiD· 2 shared Alexandra E. CuaycaliD· 1 shared Amanda L. PosgaiiD· 1 shared Ana Laura ChiodettiiD· 1 shared Andrew M. LaddiD· 1 shared Bernd BodenmilleriD· 1 shared Clive Henry WasserfalliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

Mark A. AtkinsonORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

Matthew W. Becker, Matthew E. Brown, Katherine Wiseman, Ana Laura Chiodetti, Mollie K. Huber, Alexandra E. Cuaycal, Pumin Sintara, Sandra Mara Ferreira, Dylan Smurlick, Jessie M. Barra, Andrew M. Ladd, Denise Minerva Drotar, Mark A. Atkinson, Peter Weber, Hussein Al‐Mossawi, , Edward A. Phelps

This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.

bioRxiv · Oct 21, 2025 · PreprintBioengineering

Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata

Nathan Steenbuck, Nicolas Damond, Stefanie Engler, Irina Kusmartseva, Amanda L. Posgai, Denise Minerva Drotar, MacKenzie D. Williams, Natalie de Souza, Todd M. Brusko, Maigan Brusko, Clive Henry Wasserfall, Mark A. Atkinson, Bernd Bodenmiller

The paper uses imaging mass cytometry to analyze human pancreatic samples and identifies early β-cell dysfunction and immune changes in type 1 diabetes progression.

bioRxiv · Mar 5, 2025 · PreprintImmunology