Intracranial Targeting of Cholesterol Processing Reveals a Therapeutic Vulnerability that Reprograms Glioblastoma and Promotes Antitumor Immunity
María José Ulloa-Navas, Rachel Whitehead, Vanessa K. Jones, Loizos Michaelides, Mieu Brooks, Aleeshba N. Basil, Raquel Morales‐Gallel, Cristina Gomez-Palmero, Graciela Abril Reynaga-Macias, Jesus Emiliano Sanchez-Garavito, Brianna Tapia-Dierking, Asha Nair, Juan Pablo Navarro Garcia de Llano, Paula V. Schiapparelli, Ian Dryden, , Alfredo Quiñones‐Hinojosa
This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.
bioRxiv · Aug 19, 2026 · PreprintCancer Biology