Zeynep Hulya Gumus

The genetic, clinical and immune landscape of clonal hematopoiesis across adulthood in the multi-ancestry Mount Sinai Million cohort

This study characterizes clonal hematopoiesis across adulthood and genetic ancestry in a large cohort, finding age-related increases in prevalence, ancestry-specific differences, and associations with immune markers and disease outcomes.

Inherited genetic risk factors in young-onset lung cancer

This study identifies inherited genetic risk factors in young-onset lung cancer, finding higher burdens of rare pathogenic variants in DDR and cilia-related genes and elevated polygenic risk scores.

Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

This study develops an ex vivo mouse brain slice model that mimics brain aging and shows prions accelerate aging-related molecular changes.

Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia

The paper identifies ultra-rare exonic variants in an Ashkenazi Jewish founder population, implicating cadherins in schizophrenia through recurrent mutations and altered purifying selection.

A Molecular network approach reveals shared cellular and molecular signatures between chronic fatigue syndrome and other fatiguing illnesses

This study identifies shared molecular signatures between chronic fatigue syndrome and other fatiguing illnesses using RNA-sequencing data from blood samples.

Inherited rare, deleterious variants in ATM increase lung adenocarcinoma risk

The paper identifies inherited rare, deleterious ATM variants as risk factors for lung adenocarcinoma, showing increased odds ratios in case-control studies and population cohorts.

Ancestry-Specific Predisposing Germline Variants in Cancer

The paper identifies ancestry-specific germline variants in cancer predisposition genes and their somatic effects across diverse populations.

ProNetView-ccRCC: A web-based portal to interactively explore clear cell renal cell carcinoma proteogenomics networks

ProNetView-ccRCC provides an interactive web tool to explore phosphopeptide co-expression networks in clear cell renal cell carcinoma using CPTAC data.

Dynamical rearrangement of human epidermal growth factor receptor 2 upon antibody binding: effects on the dimerization

This study uses computational modeling to investigate how anti-HER2 antibodies affect HER2 dimerization by analyzing conformational changes in key regions of the receptor.

Rare, pathogenic germline variants in Fanconi Anemia genes increase risk for squamous lung cancer

The paper identifies rare pathogenic germline variants in Fanconi Anemia genes as risk factors for squamous lung cancer, with BRCA2 showing significant enrichment.

High-depth whole genome sequencing of a large population-specific reference panel: Enhancing sensitivity, accuracy, and imputation

The paper sequenced a population-specific reference panel at high depth to improve imputation accuracy and variant filtering in the Ashkenazi Jewish population.

Exploring biological networks in 3D, stereoscopic 3D and immersive 3D with iCAVE

The paper introduces iCAVE, a 3D visualization tool for complex biological networks, and provides a guide for its use.