Jeroen van den Berg

Unified function of FACT in mammalian chromatin replication and transcription, dissolving and restoring nucleosomes to counteract genome aggregation

This study shows that FACT is essential for chromatin replication and transcription by disrupting and reassembling nucleosomes, preventing genome aggregation.

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

THE NSL COMPLEX PROMOTES NEURAL DEVELOPMENT BY PREVENTING R-LOOP INDUCED REPLICATION STRESS

This study shows the NSL complex prevents R-loop induced replication stress during neural development, leading to developmental abnormalities when disrupted.

Acute multi-level response to defective de novo chromatin assembly in S-phase

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

Acceleration of genome replication uncovered by single-cell nascent DNA sequencing

This study measures DNA replication speeds in human cells using single-cell sequencing and finds replication accelerates during S-phase, limited by transcriptional activity early in the phase.

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

The paper measures how chromatin context influences the balance between DNA repair pathways after Cas9-induced breaks in over 1,000 genomic locations.

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

The paper identifies a FOXO-dependent mechanism that restricts proliferation of cells with mild replication stress by promoting premature activation of APC/CCDH1.