CaMKIIα holoenzymes self-organize into worm-like mesoscale clusters
Taisei Suzuki, Takashi Sumikama, Keisuke Matsushima, Kodai Hasegawa, Ayumi Sumino, Kenichi Umeda, Noriyuki Kodera, Tamoghna Das, Carsten Beta, Hideji Murakoshi, Mikihiro Shibata
This study shows that CaMKII holoenzymes form worm-like mesoscale clusters under spatial confinement, with activation leading to cluster expansion and a mutant variant forming clusters even without activation.
bioRxiv · Jan 23, 2026 · PreprintNeuroscience