Hideji Murakoshi

This study shows that CaMKII holoenzymes form worm-like mesoscale clusters under spatial confinement, with activation leading to cluster expansion and a mutant variant forming clusters even without activation.

The paper uses high-speed AFM to show that CaMKII/{beta} heterododecamers form stable structures with adjacent CaMKII{beta} subunits, revealing their structural role.

This study shows that Rem2 inhibits CaMKII activity at synapses, thereby restricting long-term potentiation in the hippocampus.

The paper uses high-speed atomic force microscopy to study activity-dependent structural dynamics of CaMKII in rat, hydra, and C. elegans, revealing species-specific structural changes and phosphatase tolerance in rat CaMKII.

This study shows chronic neuronal excitation suppresses structural long-term potentiation (sLTP) through two mechanisms: inhibiting Ca2+ influx and impairing CaMKII downstream signaling.

This study identifies Rap2 and TNIK as regulators of Plexin-dependent synaptic tiling in C. elegans, showing their role in restricting presynaptic assembly and forming tiled innervation.