Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits.
Iryna Moskalevska, Larisa S. Okorokova, Raphaël Rousset, Thierry Juhel, Éric Gilson, Bérengère Dadone‐Montaudié, Laurence Bianchini, Gaël Cristofari, Julien Cherfils‐Vicini
This study shows that targeting GD3 ganglioside, a senescence-associated immune checkpoint, improves healthspan and reduces age-related diseases with sex-specific benefits in mice.
bioRxiv · Jan 7, 2026 · PreprintCell Biology