Gaël Cristofari

This study shows that targeting GD3 ganglioside, a senescence-associated immune checkpoint, improves healthspan and reduces age-related diseases with sex-specific benefits in mice.

The paper shows that reduced DNA methylation in cancer cells leads to senescence without DNA damage, involving p21 and cGAS, and demonstrates this in vivo.

The paper analyzes L1 retrotransposition in tumors using long-read sequencing, revealing synchronous L1 insertions drive chromosomal crossovers early in tumorigenesis.

The paper profiles L1 DNA methylation at single-locus resolution across normal and cancer cells, revealing how methylation and transcription interact with L1 integration sites.

The paper identifies new regulators of germline genes and 2-cell like cell state through a genome-wide CRISPR knock-out screen in mouse ES cells.

The paper describes a targeted nanopore sequencing method to sequence and analyze DNA methylation of LINE-1 retrotransposons with high coverage and haplotype resolution.

The paper shows TASOR interacts with CNOT1 and other RNA degradation factors to repress HIV expression by promoting RNA degradation and H3K9me3 deposition.

The paper develops a method to generate locus-specific chromatin profiles at transposable elements using HiChIP and PAtChER, revealing epigenetic variation in young TEs in mouse and human cells.

This study shows that let-7 microRNA reduces LINE-1 retrotransposition by inhibiting ORF2p translation in human lung cancer.

This study shows LINE-1 retrotransposition occurs in human pre-implantation embryos and extraembryonic tissues, impacting gene expression and potentially contributing to genomic variation.