Cardiomyocyte NLRP3 signaling in right heart failure is sexually dimorphic via estrogen receptor α
Rafael Sobrano Fais, Erica Das Neves Palotta, Katrina W. Kopf, Karina Mora Massad, Evandro M. Neto‐Neves, Christopher Hoffer, Avram D. Walts, Andrea L. Frump, Neil M. Goldenberg, Sophie E. Givens, Alice Bourgeois, Chen-Shan Chen Woodcock, Irina Petrache, Naomi C. Chesler, Kathleen C. Woulfe, , Tim Lahm
This study identifies a sexually dimorphic NLRP3 signaling pathway in right ventricular failure, showing estrogen receptor α mediates protection against NLRP3-induced contractile dysfunction in cardiomyocytes.
bioRxiv · Feb 14, 2026 · PreprintMolecular Biology