Sialidase-Mediated Desialylation Regulating EGFR Phosphorylation and Signal Flux
Hongyi Liu, Effram Wei, Donghai Lin, Hui Zhang
This study shows that desialylation reduces EGFR phosphorylation and signaling by affecting specific glycoforms and phosphosites, highlighting glycan remodeling as a therapeutic strategy for RTK-driven cancers.