Author

Annabel Sen

Yale UniversityORCID 0009-0003-2012-4668Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:experimental assay· 2 Organism:zebrafish· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Kayla G. TownsleyiD· 3 shared Kristen BrennandiD· 3 shared Laura M. HuckinsiD· 3 shared Meilín Fernández GarcíaiD· 3 shared April PruittiD· 2 shared Ellen J. HoffmaniD· 2 shared Grace Dossou· 2 shared Huanyao GaoiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Kayla G. TownsleyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes

April Pruitt, Liang Yang, Seoyeon Lee, Novin Balafkan, Shilin Gao, Carina Seah, Yi Dai, Elizabeth Davidson, Suha Khan, Annabel Sen, Jenny Liu, Isabel Wood, Gang Xu, Xiayuan Huang, Marina Carlson, , Kristen Brennand

The paper evaluates estradiol's effects on ASD/NDD genes using human neurons and zebrafish, finding both convergent transcriptomic effects and gene-specific cellular and behavioral rescue.

bioRxiv · Sep 19, 2026 · PreprintGenomics

Dynamic neuro-immune regulation of psychiatric risk loci in human neurons

Kayla G. Townsley, S. H. Lee, Sarah Williams, Sam Cartwright, Sophie Cohen, Annabel Sen, Meng Jia, Hannah E. Young, Lee Dobbyn, Michael Deans, Meilín Fernández García, Laura M. Huckins, Kristen Brennand

The paper investigates how maternal and fetal immune activation interacts with genetic risk profiles to influence neuronal regulatory activity and psychiatric traits.

Nature Communications · Aug 27, 2026Peer-reviewedGenetics

Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment

Meilín Fernández García, Kayla G. Townsley, April Pruitt, Elizabeth Davidson, Novin Balafkan, Jonathan Warrell, Tzu-Chieh Huang, Alfred Kibowen, Zhiyuan Chu, Yi Dai, Sarah E. Fitzpatrick, Ran Meng, Annabel Sen, Sophie Cohen, Olivia Livoti, , Kristen Brennand

This study identifies convergent biological pathways in mature neurons affected by neurodevelopmental disorder risk genes and shows drug candidates can ameliorate behavioral phenotypes.

bioRxiv · Aug 23, 2024 · PreprintGenetics