Author

Marc L. Hyer

Agios Pharmaceuticals (United States)ORCID 0009-0003-3737-1542Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alejandro Álvarez-QuilóniD· 1 shared Alexandra M. O’BrieniD· 1 shared Andrew J. ScottiD· 1 shared Angelica LiniD· 1 shared Ariya Shiwram· 1 shared Artur VelosoiD· 1 shared Ayesha U. KothariiD· 1 shared Baharan MeghdadiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Alejandro Álvarez-QuilónORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 15, 2025

A dual mechanism of sensitivity to PLK4 inhibition by RP-1664 in neuroblastoma

Isabel Soria‐Bretones, Matias Casás‐Selves, Elliot Goodfellow…·Michal Zimmermann

This study shows neuroblastoma cells are hypersensitive to PLK4 inhibitor RP-1664 due to dual mechanisms of centriole loss and amplification, leading to cell death.

5 citations

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintNov 20, 2024

Reciprocal links between methionine metabolism, DNA repair and therapy resistance in glioblastoma

Navyateja Korimerla, Baharan Meghdadi, Isra Haq…·Daniel Richard Wahl

This study identifies a metabolic link between methionine metabolism, DNA repair, and radiation resistance in glioblastoma, showing that inhibiting SAM synthesis enhances radiation efficacy.

3 citations

humanDNA methylation

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