Improving antibody-mediated protection against HSV infection by eliminating interactions with the viral Fc receptor gE/gI
Matthew D. Slein, Iara M. Backes, Lesle M Jimenez, Natasha S. Kelkar, Callaghan R. Garland, Urjeet S. Khanwalkar, Anton M. Sholukh, Christine Johnston, David A. Leib, Margaret E. Ackerman
The study shows engineered antibodies lacking Fc receptor binding improve HSV protection, suggesting vaccine strategies targeting IgG3 could enhance immunity.
Science Translational Medicine · Nov 19, 2025Peer-reviewedImmunology