Natasha S. Kelkar

This study characterizes PUB33, an Arabidopsis RLCK-IXb/PUB-VI protein, showing it has dual kinase and E3 ubiquitin ligase activities regulated by autophosphorylation and interacts with the bacterial effector RipV1 to modulate immune responses.

The study shows engineered antibodies lacking Fc receptor binding improve HSV protection, suggesting vaccine strategies targeting IgG3 could enhance immunity.

The paper identifies a humoral correlate of protection against tuberculosis in humans and non-human primates, showing cross-species and vaccine regimen consistency.