Luis Fernando Delgadillo-Silva

This study investigates the role of ER calcium stores in glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets, finding that ER mobilization is insufficient to initiate waves but required for sustained waves and connectivity.

This study monitors beta cell function in vivo over time, showing hyperglycemia disrupts Ca2+ dynamics and hub cells, while GLP1R agonism restores them.

This paper investigates sex-dependent effects of dorzagliatin and incretin on insulin secretion in a novel GCK-MODY mouse model, finding additive benefits in males but not females.

This study maps β-cell regeneration in zebrafish using single-cell transcriptomics, identifying hybrid β/δ cells as key contributors to diabetes recovery.