Jinge Gu

The paper describes a method to identify cross-β forming regions in low complexity domains that mediate self-association and phase separation.

This study shows that N-acetylation of α-synuclein enhances its ability to cluster synaptic vesicles via increased interaction with lysophosphatidylcholine.

The paper shows stress induces TDP-43 nuclear bodies via NEAT1-promoted phase separation, which protects cells from toxicity and is disrupted by an ALS mutation.

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.