Author

Yujie Zhang

University of LiverpoolORCID 0000-0002-7591-6553Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yujie Zhang4 papers · Gladstone Institutes

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Duncan SprouliD· 2 shared Francesca Taglini· 2 shared Hannah WapenaariD· 2 shared Marcus D. WilsoniD· 2 shared Willow RollsiD· 2 shared Ann P. WheeleriD· 1 shared Cristina Rubio-Ramon· 1 shared Dhananjay KumariD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Duncan SproulORCID

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2 papers

Recent·Most cited

Disease mutations in the PWWP domain of DNMT3A affect chromatin recruitment through multiple mechanisms

Hannah Wapenaar, Gillian Clifford, Francesca Taglini, Finlay McGhie, Willow Rolls, Yujie Zhang, Duncan Sproul, Marcus D. Wilson

This study examines how mutations in the PWWP domain of DNMT3A affect chromatin recruitment through different mechanisms, leading to distinct disease phenotypes.

bioRxiv · Aug 31, 2026 · PreprintBiochemistry

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

Francesca Taglini, Ioannis Kafetzopoulos, Willow Rolls, Kamila Irena Musialik, Heng Yang Lee, Yujie Zhang, Mattia Marenda, Lyndsay Kerr, Hannah Finan, Cristina Rubio-Ramon, Philippe Emmanuel Gautier, Hannah Wapenaar, Dhananjay Kumar, Hazel Davidson‐Smith, Jimi C. Wills, , Duncan Sproul

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

EMBO Reports · Jan 30, 2024Peer-reviewedGenetics