Derlin-mediated ERAD of lipid regulator ORMDL3 safeguards mitochondrial function
Nicola A. Scott, Jeremiah Afolabi, Andrea Gail Marshall, Jenny C. Schafer, Victoria R. Baskerville, Praveena Prasad, Ashlesha A. Kadam, Catherine Som de Cerff, Thomas C. Whisenant, Mark Phillips, Dhanendra Tomar, Melanie R. McReynolds, Antentor Othrell Hinton Jr., Sonya E. Neal
This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.
bioRxiv · Mar 3, 2026 · PreprintCell Biology