Ashlesha A. Kadam

This study identifies IMS proteases as regulators of mitochondrial calcium transport by remodeling mtCU and NCLX through proteolytic control, linking proteostasis to Ca2+ homeostasis.

This study identifies mitochondrial lactylation changes in myocardial infarction and shows that MCT1 inhibition alters lactylation, reduces fibrosis, and partially restores mitochondrial function.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.