Vorinostat Rescues SQSTM1 Palmitoylation and Restores Dysfunctional Autophagy in Huntington Disease
Yasmeen Alshehabi, Fatima Abrar, Milena Rabu, Anthony Dang, Firyal Ramzan, Dale D. O. Martin
bioRxiv · Mar 19, 2026 · PreprintNeuroscience
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University of WaterlooORCID 0009-0004-0366-6665Unclaimed ORCID profile · follow to get notified of new preprints
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Yasmeen Alshehabi, Fatima Abrar, Milena Rabu, Anthony Dang, Firyal Ramzan, Dale D. O. Martin
bioRxiv · Mar 19, 2026 · PreprintNeuroscience
Fatima Abrar, Martyn C. Davies, A. Kumar, A. Dang, Yvonne Nguyen, Jennifer A. Collins, Nicholas S. Caron, J.S. Choudhary, Shaun S. Sanders, Mark O. Collins, Michael R. Hayden, Dale D. O. Martin
The paper shows reduced S-acylation of SQSTM1/p62 in Huntington disease impairs autophagy by blocking autophagic flux and causing empty autophagosomes.
bioRxiv · Oct 11, 2023 · PreprintNeuroscience