Author

Leon Gehrke

Universitätsklinikum WürzburgORCID 0009-0004-0632-7589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

Barbara AltieriiD· 1 shared Hermann EinseleiD· 1 shared Justus WeberiD· 1 shared Katja Kiseljak‐VassiliadesiD· 1 shared Laura‐Sophie LandwehriD· 1 shared Marc Philipp SchaueriD· 1 shared Margaret E. WiermaniD· 1 shared Martin FaßnachtiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Barbara AltieriORCID

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1 paper

Recent·Most cited

Tumour-derived glucocorticoids amplify ROR1 and are exploited with glucocorticoid-resistant ROR1 CAR-T cells

Marc Philipp Schauer, Justus Weber, Peter Spieler, Barbara Altieri, Leon Gehrke, Silviu Sbiera, Stefan Kircher, Max Kurlbaum, Matthias Kroiß, Katja Kiseljak‐Vassiliades, Margaret E. Wierman, Thomas Nerreter, Sophia Danhof, Hermann Einsele, Martin Faßnacht, , Michael Hudecek

The paper shows that tumor-derived glucocorticoids increase ROR1 expression while suppressing T cell activity, and GC-resistant CAR-T cells can overcome this by preserving ROR1 expression in tumor cells.

bioRxiv · Jan 28, 2025 · PreprintCancer Biology