Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models
Ye-Jin Park, Tzu‐Chiao Lu, Tyler Jackson, Lindsey D. Goodman, L. Ran, Jiaye Chen, Chung‐Yi Liang, Erin M Harrison, Christina Ko, Xi Xian Chen, Baiping Wang, Ao‐Lin Hsu, Elizabeth Ochoa, Kevin F. Bieniek, Shinya Yamamoto, , Hongjie Li
The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.
Neuron · Jul 1, 2025Peer-reviewedGenetics