Author

Nikolas Klink

TU Dortmund UniversityORCID 0009-0006-4325-3528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Malte GerschiD· 2 shared Annette PascheniD· 1 shared Barbara M. GrüneriD· 1 shared Bikash AdhikariiD· 1 shared Elmar WolfiD· 1 shared Farnusch KaschaniiD· 1 shared Gian‐Marvin KipkaiD· 1 shared J KochiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Malte GerschORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 13, 2026

Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion

Nikolas Klink, Sebastian Urban, Johanna A. Seier…·Malte Gersch

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

1 citation

humanproteomics

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BiochemistryNature Structural & Molecular BiologyPeer-reviewedMay 5, 2025

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability

Nafizul Haque Kazi, Nikolas Klink, Kai Gallant…·Malte Gersch

This study identifies the structural basis for USP30 inhibition using chimeric protein engineering and provides a framework for designing specific deubiquitinase inhibitors.

26 citationstop 2%

humanstructural biology

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