ImmunologybioRxivPreprint
Selective alteration to CD4 T cell differentiation by heterozygous IRF4L116R protects against neuroinflammation
Rebecca A. Jaeger, Nadia A. Roberts, Cynthia M. Turnbull…·Anselm Enders
This study shows that a heterozygous IRF4L116R mutation selectively impairs CD4 T cell differentiation into Th1, Th17, and Treg subsets, protecting against neuroinflammation without affecting overall T cell activation or memory.
DOI 10.1101/2025.06.25.661400