Anne Brüstle

RUNX2 is a cell-intrinsic brake on Th17 pathogenicity driven by neutrophil extracellular traps

This study shows RUNX2 suppresses Th17 pathogenicity in MS and EAE by inhibiting neutrophil extracellular trap-driven Th17 priming.

Selective alteration to CD4 T cell differentiation by heterozygous IRF4L116R protects against neuroinflammation

This study shows that a heterozygous IRF4L116R mutation selectively impairs CD4 T cell differentiation into Th1, Th17, and Treg subsets, protecting against neuroinflammation without affecting overall T cell activation or memory.

Characterisation of CD4 Th subsets as well as dietary, exercise and lifestyle factors in an established Rheumatoid Arthritis cohort; pilot study.

This study examines sex-specific differences in CD4 Th subsets and lifestyle factors in a RA cohort, finding sex-related variations in Th cell frequencies and dietary patterns.

Alpha Synuclein Induced Immune Response Triggers Parkinson's Disease Like Symptoms

This study shows that autoimmune response to alpha-synuclein antigen causes Parkinson's disease-like symptoms in mice through immune cell infiltration and inflammation.

The Current Understanding of Precision Medicine and Personalised Medicine in Selected Research Disciplines: Study Protocol of a Systematic Concept Analysis

This paper conducts a systematic concept analysis to clarify the understanding and distinctions of 'precision medicine' and 'personalised medicine' across multiple disciplines.