Author

Dominik Spensberger

Australian National UniversityORCID 0000-0002-9798-2949Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Adrian F. LoiD· 1 shared Alexandra J. SpenceriD· 1 shared Andrea DoiD· 1 shared Anne Brüstle· 1 shared Anselm EndersiD· 1 shared Cynthia M. TurnbulliD· 1 shared Daniel Fernandez‐RuiziD· 1 shared Daniel H.D. GrayiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Adrian F. LoORCID

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3 papers

Recent·Most cited

B cells targeting parasites capture spatially linked antigens to secure T cell help

Xin Gao, Hayley A. McNamara, Jiwon Lee, Adrian F. Lo, Deepyan Chatterjee, Dominik Spensberger, Daniel Fernandez‐Ruiz, Kevin Walz, Ke Wang, Hannah G. Kelly, Kai G. Pohl, Patricia E. Carreira, Andrea Do, Le Xiong, Lynette Beattie, , Ian Andrew Cockburn

The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.

Science Immunology · Nov 7, 2025Peer-reviewedImmunology

Selective alteration to CD4 T cell differentiation by heterozygous IRF4L116R protects against neuroinflammation

Rebecca A. Jaeger, Nadia A. Roberts, Cynthia M. Turnbull, Sandali Seneviratne, Rebecca L. Buckland, Dominik Spensberger, Jessica A. Pettitt, Fiona D. Ballard, Anne Brüstle, Anselm Enders

This study shows that a heterozygous IRF4L116R mutation selectively impairs CD4 T cell differentiation into Th1, Th17, and Treg subsets, protecting against neuroinflammation without affecting overall T cell activation or memory.

bioRxiv · Jun 25, 2025 · PreprintImmunology

SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells

Özgen Deniz, Lorenzo de la Rica, Kevin C. L. Cheng, Dominik Spensberger, Miguel Ramos Branco

This study shows that SETDB1 prevents TET2 from demethylating H4R3 in IAP retroelements in naive ESCs, maintaining their silencing.

Genome biology · Jan 19, 2018Peer-reviewedGenetics