Functional Pairing of TCR-peptide-MHC Interactomes by Single-cell Clonal Expansion
Liu Daisy Liu, Seung Won Shin, Kevin M. Joslin…·K. Christopher García
The paper develops LINC-seq to identify functional TCR-pMHC pairs by clonal expansion and deep mutational scanning, achieving high accuracy in recovering known cognate pairs and resolving co-evolutionary interactions.