Travis Perryman

This study shows that glutamatergic neuron-tumor synapses influence glioblastoma cell states by modulating radial glia plasticity and transcriptional programs.

The paper maps clonal hierarchies in glioblastoma using lineage-resolved single-cell data, revealing multiple non-redundant progenitors and identifying cell type-specific therapeutic targets.

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

The paper uses single-nucleus RNA-sequencing to compare non-enhancing and contrast-enhancing regions of high-grade gliomas, finding distinct cellular states and microenvironment features in NE regions.