Kunal S. Patel

Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticity

This study shows that glutamatergic neuron-tumor synapses influence glioblastoma cell states by modulating radial glia plasticity and transcriptional programs.

Predictable clonal hierarchies from restricted progenitors provide a framework for cell type-specific therapies in glioblastoma

The paper maps clonal hierarchies in glioblastoma using lineage-resolved single-cell data, revealing multiple non-redundant progenitors and identifying cell type-specific therapeutic targets.

Critical role of cell competition in gliomagenesis

This study identifies cell competition as a key driver of gliomagenesis by showing that pre-malignant OPCs outcompete wildtype cells, and inhibiting this process reduces tumor growth.

Human Organoid Tumor Transplantation Identifies Functional Glioblastoma - Microenvironmental Communication Mediated by PTPRZ1

The paper uses a human organoid tumor transplantation system to study glioblastoma-microenvironment interactions, identifying PTPRZ1 as a key mediator of intercellular communication.

A Human Tumor-Immune Organoid Model of Glioblastoma

Autologous co-culture of patient glioblastoma cells and matched peripheral blood mononuclear cells in human cortical organoids (iHOTT) preserves tumor-immune crosstalk and recapitulates patient T cell responses to pembrolizumab.

A neurovascular progenitor sits at the nexus of glioblastoma lineage trajectories

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

Single-nucleus analysis characterizes non-enhancing region of recurrent high-grade glioma

The paper uses single-nucleus RNA-sequencing to compare non-enhancing and contrast-enhancing regions of high-grade gliomas, finding distinct cellular states and microenvironment features in NE regions.