Author

Leykashree Nagendren

Duke UniversityORCID 0009-0004-5405-7595Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Çağla EroğluiD· 3 shared Kristina SakersiD· 3 shared Caitlin E. PaisleyiD· 1 shared Dhanesh Sivadasan BinduiD· 1 shared Dolores IralaiD· 1 shared Erik J. SoderblomiD· 1 shared Francesca MazzoniiD· 1 shared Francesco Paolo Ulloa SeverinoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Çağla EroğluORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.

Kristina Sakers, Juan J. Ramirez, Nimrod Elazar, Leykashree Nagendren, Erik J. Soderblom, Çağla Eroğlu

This study identifies Nedd4l-mediated ubiquitination of NL2 as essential for astrocyte morphogenesis during development.

The Journal of Cell Biology · Apr 30, 2026Peer-reviewedCell Biology

Phosphatidylserine exposure by developing astrocytes initiates microglia-mediated developmental cell death

Caitlin E. Paisley, Kristina Sakers, Leykashree Nagendren, Xi Chen, Francesca Mazzoni, Silvia C. Finnemann, Çağla Eroğlu, Jeremy N. Kay

The paper shows that phosphatidylserine exposure by developing astrocytes triggers microglia-mediated cell death, leading to vascular defects in the retina and cerebral cortex.

bioRxiv · Jan 21, 2026 · PreprintNeuroscience

Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function

Dolores Irala, Shiyi Wang, Kristina Sakers, Leykashree Nagendren, Francesco Paolo Ulloa Severino, Dhanesh Sivadasan Bindu, Justin T Savage, Çağla Eroğlu

This study identifies Neurocan as an astrocyte-secreted protein that promotes inhibitory synapse formation and function through its C-terminal fragment.

Neuron · Apr 3, 2024Peer-reviewedNeuroscience