Author

Lea Lortal

Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA;ORCID 0009-0004-6221-7763Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Adrian Lau· 1 shared Aize PellóniD· 1 shared Alexander KempfiD· 1 shared Andrew J. Donkin· 1 shared Angela L. Wei· 1 shared Ankur AnkuriD· 1 shared Don N. WickramasingheiD· 1 shared Emily L. PriestiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

Adrian Lau

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintNov 2, 2026

Therapeutic vulnerabilities of the drug-resistant fungal meningitis pathogen Cryptococcus neoformans

Manning Y. Huang, Patrick Hecht, Kyle Cesar…·Hiten D. Madhani

This study identifies therapeutic vulnerabilities in Cryptococcus neoformans using CRISPR-insert and machine learning, revealing new drug targets and synthetic lethal dependencies.

DOI 10.64898/2026.10.31.763343

C. elegansexperimental assay

MicrobiologybioRxivPreprintApr 10, 2026

The IL-1 Family Controls Acute Mucosal Fungal Infection and Mucosal-Systemic Dissemination.

James S. Griffiths, Alexander Kempf, Robert J. Pickering…·Julian R. Naglik

This study shows the IL-1 family is essential for mucosal defense against Candida albicans, preventing infection and dissemination, but its absence in neutropenic conditions leads to fatal systemic infection.

DOI 10.64898/2026.04.10.717440

humanexperimental assay