Ankur Ankur

Therapeutic vulnerabilities of the drug-resistant fungal meningitis pathogen Cryptococcus neoformans

This study identifies therapeutic vulnerabilities in Cryptococcus neoformans using CRISPR-insert and machine learning, revealing new drug targets and synthetic lethal dependencies.

Distinguishing Polymer Turnover from De Novo Biosynthesis Reveals Dynamic Cell Wall Remodeling During Aspergillus fumigatus Conidial Germination

The paper distinguishes polymer turnover from de novo biosynthesis in Aspergillus fumigatus during conidial germination using isotope-edited solid-state NMR, revealing dynamic cell wall remodeling.

Dynamic Reprogramming of Fungal Cell Walls Underlies Germination and Immune Exposure in Zygomycetous Fungal Pathogens

This study shows how the cell wall of Rhizopus delemar reprograms during germination, enhancing immune recognition, and identifies key polysaccharide changes involved.

Molecular Architecture of Cryptococcus Cell Walls Reveals Species-Specific Chitosan-Dependent Remodeling

This study examines the structural role of chitosan in Cryptococcus cell walls, revealing species-specific remodeling effects when chitosan is absent.

α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in an Aspergillus fumigatus Vaccine Strain Alters Innate Immune Recognition

This study investigates how cell-wall remodeling in an Aspergillus fumigatus vaccine strain affects innate immune recognition through structural and functional analyses.

Polymorphic α-Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights from 13C and 1H Solid-State NMR

This study uses solid-state NMR to reveal five structural forms of α-glucans in Cryptococcus cell walls, showing their role in scaffolding and interacting with chitin, capsule, and melanin.