Author

Rui Liang

Nankai UniversityORCID 0009-0004-6748-5142Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Rui Liang1 paper · Xi'an Jiaotong University

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Huixia ReniD· 2 shared Lanqiu Zhang· 2 shared Shusen WangiD· 2 shared Tengli Liu· 2 shared Wenmiao Ma· 2 shared Alyna KattiiD· 1 shared Benjamin I. LeachiD· 1 shared Brandon F Malone· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersDevelopmental Biology

Huixia RenORCID

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3 papers

Recent·Most cited

Pancreatic Duct Cells as a Potential Source for Human Islet Neogenesis: Insights from Imaging Mass Cytometry

Rui Liang, Tengli Liu, Lanqiu Zhang, Wenmiao Ma, Huixia Ren, Shusen Wang

The paper uses imaging mass cytometry to analyze pancreatic duct-associated endocrine cells across age groups, finding changes in cell types and abundance linked to diabetes, obesity, and aging.

bioRxiv · Feb 10, 2026 · PreprintDevelopmental Biology

A spatial-temporal atlas of human islet pathophysiology identifies a size-dependent trajectory from compensation to decompensation

Tengli Liu, Rui Liang, Lanqiu Zhang, Wenmiao Ma, Xiangyu WANG, Huixia Ren, Shusen Wang

This study identifies a size-dependent trajectory of islet remodeling in T2D, showing medium and large islets correlate with glycemic failure while small islets show compensatory responses.

bioRxiv · Feb 1, 2026 · PreprintPathology

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression

Jill Zimmerman, Brandon F Malone, Efrat Finkin-Groner, Shan Sun, Rui Liang, Miguel Foronda, Emma M. Schatoff, Elizabeth Granowsky, Sukanya Goswami, Alyna Katti, Benjamin I. Leach, Heather L. Alcorn, Tuomas Tammela, Yoshiyuki Fukase, Tanweer A. Khan, , Lukas E. Dow

The paper identifies a TNKS2-selective inhibitor that enables tumor-selective WNT suppression by exploiting 8p loss in cancer cells.

bioRxiv · Mar 4, 2025 · PreprintCancer Biology