Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC
Salvador Alonso, Kevan Chu, Marie J. Parsons, Elizabeth Granowsky, Himari Imaya Gunasinghe, Jinru Shia, Rona D. Yaeger, Lukas E. Dow
This study identifies genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC using single-cell spatial transcriptomics and exome sequencing, revealing inflammatory and fetal-like transcriptional signatures associated with resistance.
bioRxiv · Aug 5, 2025 · PreprintCancer Biology