Gauthier Brach

Population-scale chemical response revealed by a barcoded yeast collection

The paper develops a barcoded yeast collection to map genotype-phenotype relationships across genetic diversity, revealing genetic variants linked to chemical responses.

Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeast

The paper uses a diallel panel of yeast hybrids to show low-frequency SNPs have a larger impact on gene expression than common SNPs or SVs.

Recurrent loss of crossover interference punctuates the recombination landscape across yeast species

The paper analyzes meiotic recombination landscapes across five yeast species, finding species-specific differences in recombination rates, crossover interference, and hotspot conservation.

Non-additive genetic components contribute significantly to population-wide gene expression variation

The paper estimates heritability of gene expression traits in yeast hybrids and finds non-additive components account for 36% of phenotypic variance.