Anne Friedrich

The paper analyzes allopolyploidization events in Brettanomyces bruxellensis using graph pangenomes to identify structural variants and their functional impacts.

The paper investigates nitrate assimilation in B. bruxellensis lineages using genomic and phenotypic data, finding it is widespread but unevenly distributed and influenced by gene copy number and functionality.

The paper develops a barcoded yeast collection to map genotype-phenotype relationships across genetic diversity, revealing genetic variants linked to chemical responses.

This study identifies Reg1 mutations that confer resistance to 2-deoxyglucose in yeast by disrupting its role in Snf1 inhibition.

This study uses whole-genome sequencing to analyze 145 Lachancea thermotolerans strains, revealing genetic and phenotypic adaptations to the winemaking environment.

The paper analyzes 3,034 Saccharomyces cerevisiae genomes to characterize population structure, revealing 93% species diversity and ecological clustering patterns.

The paper analyzes the pan-transcriptome of yeast isolates to show that accessory genes significantly contribute to gene expression variation across populations.

The paper quantifies transcriptomes and proteomes across 942 yeast isolates, showing weak correlation between mRNA and protein levels and distinct genetic control mechanisms.

The paper uses a diallel panel of yeast hybrids to show low-frequency SNPs have a larger impact on gene expression than common SNPs or SVs.

The paper analyzes meiotic recombination landscapes across five yeast species, finding species-specific differences in recombination rates, crossover interference, and hotspot conservation.

The paper examines translation variation across yeast genetic backgrounds and identifies a post-transcriptional buffering signature that affects essential genes and low-transcribed genes.

The paper shows that absence of Red1 and Hop1 recruitment prevents meiotic recombination on a chromosome arm containing the sex locus in Lachancea kluyveri, affecting genome evolution and fitness.

This paper presents 142 high-quality yeast genomes to improve pangenome understanding, identifying structural variants and complex genomic regions.

This study compares genomic evolution between domesticated and wild Kluyveromyces lactis yeast populations, finding reduced diversity and gene introgression in domesticated strains.

The paper analyzes meiotic recombination in Lachancea waltii, identifying differences in crossover distribution, LOH events, and recombination hotspots compared to related species.

The paper identifies background-dependent fitness genes in yeast by analyzing loss-of-function mutations across natural isolates, finding most show continuous variation while some are specific to genetic backgrounds.

The paper analyzes polyploidization events in Brettanomyces bruxellensis yeast using long-read sequencing to reveal distinct genomic trajectories and donor origins.

The paper shows that Saccharomycodes ludwigii undergoes meiosis without recombination, relying on frequent fertilization within tetrads instead.

This study identifies genetic factors underlying metabolic differences between flor and wine yeasts during fermentation, revealing adaptive divergence and potential for improving oenological traits.

The paper analyzes Ty LTR-retrotransposon content across 1,011 Saccharomyces cerevisiae isolates to trace evolutionary history and identify factors shaping TE repertoires.

nPhase is a polyploidy-agnostic phasing method that achieves high accuracy and contiguity in haplotype prediction for polyploid genomes.

The paper identifies QTL hotspots in Lachancea waltii for growth fitness and shows they are not conserved in a closely related species.

This study identifies two distinct domestication trajectories in Saccharomyces cerevisiae linked to industrial and sourdough bread-making processes, revealing autotetraploidisation as a driver of divergence.

The paper analyzes mitochondrial and nuclear genomes of Saccharomyces cerevisiae to show discordant evolutionary patterns between the two genomes.

The paper investigates the phenotypic impact of a large non-recombining introgressed region in Lachancea kluyveri yeast, identifying loci affecting growth and gene expression.

The paper sequenced 53 Brettanomyces bruxellensis genomes to study genetic variation and its relationship with ploidy level and gene content.

This paper identifies Dog1 and Dog2 as 2DG detoxication enzymes in yeast, showing their regulation by signaling pathways and their role in 2DG resistance, with implications for human cancer therapy.

The paper uses Hi-C to assemble genomes from a mixed beer sample, identifying a novel yeast hybrid between Pichia membranifaciens and an undescribed yeast.

The paper presents a high-quality de novo genome assembly of Dekkera bruxellensis UMY321 using Nanopore and Illumina sequencing, providing insights into genomic variability within the species.

The paper examines meiotic recombination differences between Saccharomyces cerevisiae and Lachancea kluyveri, finding significant variations in recombination rates, crossover patterns, and hotspot conservation across evolutionary distances.