John Joseph Kelly

Pannexin 1 Ablation Disrupts Cell Cycle Progression and Compromises the Structure of Melanoma Tumours

This study shows that PANX1 ablation disrupts cell cycle progression and tumor structure in melanoma, suggesting it as a therapeutic target.

Pannexin 1 inhibition reduces tumorigenic properties of patient-derived glioblastoma cells through the HIPPO and Wnt signalling pathways

Imaging CRISPR-Edited CAR-T Cell Therapies with Optical and Positron Emission Tomography Reporters

This paper develops tRACE-CAR T cells with optical and PET imaging reporters to track CAR-T cell distribution and activity in vivo, showing improved tracking and therapeutic effectiveness.

Novel carboxy-terminal Pannexin 1 isoform is expressed in mouse melanoma cells and interacts with the full-length protein