Author

Desiree Francis

University of GuelphORCID 0009-0004-9003-5043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Rebecca S. ShapiroiD· 2 shared Abdul-Rahman Adamu BukariiD· 1 shared Aleeza C. GersteiniD· 1 shared Anthony HendriksiD· 1 shared Chris Grant· 1 shared Christian R. LandryiD· 1 shared Christina A. CuomoiD· 1 shared Clara FikryiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Rebecca S. ShapiroORCID

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2 papers

Recent·Most cited

Pooled CRISPRi screening reveals fungal-specific vulnerabilities across environments and genetic backgrounds

Lauren F. Wensing, Philippe C Després, Desiree Francis, Meea Fogal, Anthony Hendriks, Nicholas C Gervais, Clara Fikry, Abdul-Rahman Adamu Bukari, Aleeza C. Gerstein, Christina A. Cuomo, Rebecca S. Shapiro

This study uses pooled CRISPRi screening in Candida albicans to identify dosage-sensitive genes across diverse environments and genetic backgrounds, highlighting potential antifungal targets.

bioRxiv · Jan 8, 2026 · PreprintMicrobiology

A role for the putative error-prone polymerase REV1 in DNA damage and antifungal drug resistance in Candida albicans

Michelle R. Agyare-Tabbi, Deeva Uthayakumar, Desiree Francis, Laetitia Maroc, Chris Grant, Peter McQueen, Garret Westmacott, Hajer Shaker, Iwona Skulska, Isabelle Gagnon‐Arsenault, Jonathan Boisvert, Christian R. Landry, Rebecca S. Shapiro

This study investigates the role of REV1, an error-prone polymerase, in DNA damage and antifungal drug resistance in Candida albicans, finding that its deletion increases mutation rates and resistance.

npj Antimicrobials and Resistance · Nov 29, 2024Peer-reviewedMicrobiology