Author

Hayley Zimny

Oregon Health & Science UniversityORCID 0009-0005-0747-318XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Motoyuki TsudaiD· 3 shared Rosalie C. SearsiD· 3 shared Alexander SmithiD· 2 shared Aubry Matter· 2 shared Colin J. DanieliD· 2 shared Dove J. Keith· 2 shared Isaac Youm· 2 shared Jonathan Robert BrodyiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Motoyuki TsudaORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 15, 2025

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway

Motoyuki Tsuda, Dove J. Keith, Colin J. Daniel…·Rosalie C. Sears

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

DOI 10.64898/2025.12.12.693851

humanbulk RNA-seq

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Cell BiologybioRxivPreprintMay 13, 2025

PIN1 Drives Cellular Plasticity and Immune Modulation in Chronic Pancreatitis

Vidhi M. Shah, Alexandra Q. Bartlett, Canping Chen…·Rosalie C. Sears

This study shows PIN1 promotes cellular plasticity and immune changes in chronic pancreatitis, with genetic or pharmacological inhibition reducing disease severity.

DOI 10.1101/2025.05.13.653850

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintFeb 11, 2025

Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression

Despoina Kalfakakou, Daniel C. Cameron, Emily A. Kawaler…·Diane M. Simeone

This study analyzes clonal heterogeneity in human pancreatic ductal adenocarcinoma using single-cell and spatial transcriptomics, revealing transcriptional continua, clonal transitions, and spatially dispersed clones associated with metastasis.

5 citations

humanscRNA-seq

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